Dan Ballard has also been handed a return to the starting XI at Coventry’s CBS Arena.
The build-up to tonight’s game was dominated by discussions over whether it would be Isidor or Mayenda playing in attack as Sunderland look to achieve a positive result to take back to Wearside ahead of Tuesday’s second leg at the Stadium of Light.
In fact, both players are starting, with Le Bris understood to be switching to a 4-4-2 formation when Sunderland have possession. That will mean Enzo Le Fee playing on the left-hand side.
With Patrick Roberts lining up on the right, there is no place for teenage midfielder Chris Rigg in the starting line-up.
Ballard is back in the side after proving his fitness during a substitute outing in last weekend’s home defeat to QPR.
The Northern Ireland international will partner Luke O’Nien at centre-half, with Chris Mepham dropping down to the substitutes’ bench.
Coventry boss Frank Lampard has made two changes to the side that beat Middlesbrough at the weekend to secure their place in the play-offs.
Jay Dasilva returns from suspension to replace Jake Bidwell at left-back, while Brandon Thomas-Asante leads the line in attack, with former Sunderland forward Ellis Simms dropping down to the bench.
COVENTRY (4-2-3-1): Wilson; van Ewijk, Thomas, Kitching, Dasilva; Grimes, Sheaf; Sakamoto, Rudoni, Wright; Thomas-Asante.
Subs: Collins (gk), Binks, Bidwell, Latibeaudiere, Eccles, Allen, Mason-Clark, Paterson, Simms.
SUNDERLAND (4-4-2): Patterson; Hume, Ballard, O’Nien, Cirkin; Roberts, Neil, Bellingham, Le Fee; Isidor, Mayenda.
Subs: Moore (gk), Browne, Rigg, Samed, Seelt, Mepham, Hjelde, Watson, Jones.