Lenihan has endured a nightmare 18 months with injuries but is back in the squad at Hillsborough, joining George Edmundson and Dael Fry on the bench, with Jonny Howson keeping his place in the backline.
Michael Carrick has named the same side that started against Plymouth on Friday, meaning Marcus Forss, Morgan Whittaker and Finn Azaz again support Tommy Conway.
Anfernee Dijksteel, Rav van den Berg and Samuel Iling-Junior join Howson in the defence, with Aidan Morris and Hayden Hackney starting in midfield.
There are two changes on the bench, with Lenihan and Law McCabe replacing Bailey and Anton Palmer.
MIDDLESBROUGH: Travers, Dijksteel, Howson, van den Berg, Iling-Junior; Hackney, Morris; Forss, Whittaker, Azaz, Conway
SUBS: Glover, Barlaser, Fry, Iheanacho, Burgzorg, Edmundson, Lenihan, Giles, McCabe
SHEFFIELD WEDNESDAY: P. Charles, Valery, Otegbayo, Johnson, S. Charles, Ingelsson, Bannan (c), Gassama, Windass, Paterson, Smith
SUBS: Beadle, Palmer, Hatsuse, Chalobah, Armstrong, Musaba, J. Lowe, Kobacki, McNeill
