Isidor replaces Alan Browne in the side, with Dennis Cirkin coming in for Leo Hjelde and Tommy Watson starting on the left flank instead of Romaine Mundle.
It’s Watson’s first start since mid-December with the winger having returned to action from the bench in the weekend win over Cardiff City.
Jobe Bellingham starts in midfield despite the teenager being one yellow card away from a two-match ban. Tonight’s game is the last match before the suspension cut-off.
Chris Rigg is again on the bench for the Black Cats, as are the three players who’ve dropped out of the side.
SUNDERLAND: Patterson, Hume, Mepham, O’Nien, Cirkin, Roberts, Neil, Bellingham, Watson, Mayenda, Isidor
SUBS: Moore, Browne, Rigg, Mundle, Seelt, Aleksic, Hjelde, Anderson, Jones
PRESTON: Woodman; Porteous, Gibson, Hughes, Kesler-Hayden, Thordarson, Ledson (c), Meghoma, Potts, Greenwood, Riis.
SUBS: Cornell, Bauer, Lindsay, Whiteman, Brady, Carroll, Frokjaer, Keane, Evans.
